Amino acid replacements leading to temperature-sensitive defects of the NS1 protein of influenza A virus.

doi:10.1007/BF01314970

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Article

Amino acid replacements leading to temperature-sensitive defects of the NS1 protein of influenza A virus.

Archives of virology - 1 Jan 1995

Ludwig S, Vogel U, Scholtissek C

Abstract excerpt

The nonstructural (NS) genes of two influenza virus temperature-sensitive (ts) reassortants have been sequenced and compared with the corresponding wild type sequences. Ts 412 has a single base substitution (G100-->A) leading to an amino acid replacement (Arg 25-->Lys) in the NS1 protein. Ts 451...

Topics

Influenza A virus
Mutation
RNA, Messenger
Structure-Activity Relationship
Temperature
Transcription, Genetic
Viral Nonstructural Proteins

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