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Article

Identification of the sites for suppressor mutations on the hemagglutinin molecule to temperature-sensitive phenotype of the influenza virus.

Microbiology and immunology - 1 Jan 1995

Tong N, Nakajima K, Nakajima S

Abstract excerpt

A temperature-sensitive (ts) mutant of the influenza virus A/WSN/33 strain, ts-134, possessed a defect in intracellular transport at the nonpermissive temperature and marked thermolability of hemagglutinin (HA) activity at 51 C. These were caused by a change at amino acid residue 157 from tyrosine to histidine in the HA protein. We isolated 37 spontaneous revertant clones from ts-134 at the nonpermissive...

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Identifiers

PMID: 8577282
DOI: 10.1111/j.1348-0421.1995.tb03257.x

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