Article
Nucleotide sequence and some biological properties of the NS gene of a newly isolated influenza B virus mutant which has a long carboxyl terminal deletion in the NS1 protein.
Virology - 1 Jan 1990
Tobita K, Tanaka T, Odagiri T, Tashiro M, Feng S Y
Abstract excerpt
By a heterotypic cross between influenza viruses A/WSN (H1N1) and B/Yamagata/1/73, we obtained a mutant of B/Yamagata (AWBY-234), which expressed a greatly truncated NS1 protein with molecular weight of 13,500. Direct sequencing of the NS gene of the mutant revealed a deletion of a single uridine base at the position 310, 311, or 312 of the plus sense RNA, giving rise to a new stop codon at the position 314-316....
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Capsid
- Cell Line
- Cytopathogenic Effect, Viral
- Influenza B virus
- Molecular Sequence Data
- Molecular Weight
- Mutation
- RNA, Viral