Article
Prediction of functional nonsynonymous single nucleotide polymorphisms in human G-protein-coupled receptors.
Journal of human genetics - 1 Jan 2008
Xue Dan, Yin Jingyuan, Tan Mingfeng, Yue Junjie, Wang Yuelan, Liang Long
Abstract excerpt
G-protein-coupled receptors (GPCRs) are found in a wide range of organisms and are central to a cellular signaling network that regulates many basic physiological processes. GPCRs are the focus of a significant amount of current pharmaceutical research because they play a key role in many diseases. In this paper, we predict the functional nonsynonymous single nucleotide polymorphisms (nsSNPs) in human GPCRs by...
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