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Genetic Variations and Polymorphisms of G Protein-Coupled Receptors: Functional and Therapeutic Implications

1 Apr 2001

Abstract excerpt

G protein-coupled receptors (GPCRs) represent a major class of proteins in the genome of many species, including humans. In addition to the mapping of a number of human disorders to regions of the genome containing GPCRs, a growing body of literature has documented frequently occurring variations (i.e. polymorphisms) in GPCR loci. In this article, we use a domain-based approach to systematically examine examples...

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PMID: 11264470
DOI: 10.1146/annurev.pharmtox.41.1.593

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