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Article

Approaches and resources for prediction of the effects of non-synonymous single nucleotide polymorphism on protein function and interactions.

Current pharmaceutical biotechnology - 1 Apr 2008

Teng S, Michonova-Alexova E, Alexov E

Abstract excerpt

Almost all (99.9%) nucleotide bases are exactly the same in all people, however, the remaining 0.1% account for about 1.4 million locations where single-base DNA differences/polymorphisms (SNPs) occur in humans. Some of these SNPs, called non-synonymous SNPs (nsSNPs), result in a change of the amino acid sequences of the corresponding proteins affecting protein functions and interactions. This review summarizes...

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PMID: 18393868
DOI: 10.2174/138920108783955164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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