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Article

Prediction of the phenotypic effects of non-synonymous single nucleotide polymorphisms using structural and evolutionary information.

Bioinformatics (Oxford, England) - 15 May 2005

Bao Lei, Cui Yan

Abstract excerpt

MOTIVATION: There has been great expectation that the knowledge of an individual's genotype will provide a basis for assessing susceptibility to diseases and designing individualized therapy. Non-synonymous single nucleotide polymorphisms (nsSNPs) that lead to an amino acid change in the protein product are of particular interest because they account for nearly half of the known genetic variations related to...

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PMID: 15746281
DOI: 10.1093/bioinformatics/bti365

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