Article
GPCR NaVa database: natural variants in human G protein-coupled receptors.
Human mutation - 1 Jan 2008
Kazius Jeroen, Wurdinger Kerstin, van Iterson Maarten, Kok Joost, Bäck Thomas, Ijzerman Ad P
Abstract excerpt
The superfamily of human G protein-coupled receptors (GPCRs) is large and regulates a plethora of important physiological processes by transducing extracellular signals over cell membranes. A diversity of natural variants occurs in these receptors, including rare mutations and common polymorphisms. These variants differ in their impact on DNA, ranging from single nucleotide polymorphisms (SNPs) to copy number...
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