Article
Delineation of the protein module that anchors HMGN proteins to nucleosomes in the chromatin of living cells.
Molecular and cellular biology - 1 May 2008
Ueda Tetsuya, Catez Frédéric, Gerlitz Gabi, Bustin Michael
Abstract excerpt
Numerous nuclear proteins bind to chromatin by targeting unique DNA sequences or specific histone modifications. In contrast, HMGN proteins recognize the generic structure of the 147-bp nucleosome core particle. HMGNs alter the structure and activity of chromatin by binding to nucleosomes; however, the determinants of the specific interaction of HMGNs with chromatin are not known. Here we use systematic...
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