Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo.

Nature structural & molecular biology - 1 Mar 2006

Brown David T, Izard Tina, Misteli Tom

Abstract excerpt

H1 linker histones stabilize the nucleosome, limit nucleosome mobility and facilitate the condensation of metazoan chromatin. Here, we have combined systematic mutagenesis, measurement of in vivo binding by photobleaching microscopy, and structural modeling to determine the binding geometry of the globular domain of the H1(0) linker histone variant within the nucleosome in unperturbed, native chromatin in vivo....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Fluorescence Recovery After Photobleaching

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histones

Share to Models, Molecular

Share to Nucleosomes

Share to Protein Binding

Share to Protein Interaction Mapping

Share to Recombinant Fusion Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 16462749
DOI: 10.1038/nsmb1050
PMCID: PMC1868459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo.PMID 16462749Read ↗

Emerging roles of linker histones in regulating chromatin structure and function.Semantic proximity Read ↗

Position and orientation of the globular domain of linker histone H5 on the nucleosome.Semantic proximity Read ↗

Single-base resolution mapping of H1-nucleosome interactions and 3D organization of the nucleosome.Semantic proximity Read ↗

Single-Molecule Studies of the Linker Histone H1 Binding to DNA and the Nucleosome.Semantic proximity Read ↗

Molecular architecture of heterochromatin at the nuclear periphery of primary human cellsSemantic proximity Read ↗

Cancer mutations rewire linker histone interaction network and compromise chromatosome stability.Semantic proximity Read ↗

The dynamics of histone H1 function in chromatin.Semantic proximity Read ↗

Chromatin condensing functions of the linker histone C-terminal domain are mediated by specific amino acid composition and intrinsic protein disorder.Semantic proximity Read ↗

The missing linker: emerging trends for H1 variant-specific functions.Semantic proximity Read ↗

Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding.Semantic proximity Read ↗

Behaviors of nucleosomes with mutant histone H4s in euchromatic domains of living human cells.Semantic proximity Read ↗

Differential In Vivo Binding Dynamics of Somatic and Oocyte-specific Linker Histones in Oocytes and During ES Cell Nuclear TransferSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.