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Article

Nucleosome-binding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA.

Genes & development - 1 Apr 2009

Sekiya Takashi, Muthurajan Uma M, Luger Karolin, Tulin Alexei V, Zaret Kenneth S

Abstract excerpt

FoxA proteins are pioneer transcription factors, among the first to bind chromatin domains in development and enable gene activity. The Fox DNA-binding domain structurally resembles linker histone and binds nucleosomes stably. Using fluorescence recovery after photobleaching, we found that FoxA1 and FoxA2 move much more slowly in nuclei than other transcription factor types, including c-Myc, GATA-4, NF-1, and...

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Identifiers

PMID: 19339686
DOI: 10.1101/gad.1775509
PMCID: PMC2666343

Genes

HMGB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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