Article
Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin.
Molecular and cellular biology - 1 Aug 2001
Prymakowska-Bosak M, Misteli T, Herrera J E, Shirakawa H, Birger Y, Garfield S, Bustin M
Abstract excerpt
Condensation of the chromatin fiber and transcriptional inhibition during mitosis is associated with the redistribution of many DNA- and chromatin-binding proteins, including members of the high-mobility-group N (HMGN) family. Here we study the mechanism governing the organization of HMGN proteins in mitosis. Using site-specific antibodies and quantitative gel analysis with proteins extracted from synchronized...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.