Article
Alpha-catenin is essential in intestinal adenoma formation.
Proceedings of the National Academy of Sciences of the United States of America - 13 Nov 2007
Shibata Hiroyuki, Takano Hiroshi, Ito Masaki, Shioya Hisashi, Hirota Morihisa, Matsumoto Hiroshi, Kakudo Yuichi, Ishioka Chikashi, Akiyama Tetsu, Kanegae Yumi, Saito Izumu, Noda Tetsuo
Abstract excerpt
A loss-of-function mutation in the APC gene initiates colorectal carcinogenesis. Although the molecular mechanism of tumor initiation is complex, several modifier genes have been identified using mouse models, including the ApcMin mouse. Among the familial adenomatous polyposis mouse lines carrying a truncation mutation at codon 580 in Apc (Apc580D), one line (line19-Apc(580D/+)) showed a remarkably reduced...
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