Article
Characterizing complex dynamics in the transactivation response element apical loop and motional correlations with the bulge by NMR, molecular dynamics, and mutagenesis.
Biophysical journal - 1 Oct 2008
Dethoff Elizabeth A, Hansen Alexandar L, Musselman Catherine, Watt Eric D, Andricioaei Ioan, Al-Hashimi Hashim M
Abstract excerpt
The HIV-1 transactivation response element (TAR) RNA binds a variety of proteins and is a target for developing anti-HIV therapies. TAR has two primary binding sites: a UCU bulge and a CUGGGA apical loop. We used NMR residual dipolar couplings, carbon spin relaxation (R(1) and R(2)), and relaxati...
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