Article
Characterizing complex dynamics in the transactivation response element apical loop and motional correlations with the bulge by NMR, molecular dynamics, and mutagenesis.
Biophysical journal - 1 Oct 2008
Dethoff Elizabeth A, Hansen Alexandar L, Musselman Catherine, Watt Eric D, Andricioaei Ioan, Al-Hashimi Hashim M
Abstract excerpt
The HIV-1 transactivation response element (TAR) RNA binds a variety of proteins and is a target for developing anti-HIV therapies. TAR has two primary binding sites: a UCU bulge and a CUGGGA apical loop. We used NMR residual dipolar couplings, carbon spin relaxation (R(1) and R(2)), and relaxation dispersion (R(1rho)) in conjunction with molecular dynamics and mutagenesis to characterize the dynamics of the TAR...
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