Article
Complement factor H gene polymorphism and risk of cardiovascular disease in end-stage renal disease patients.
Clinical immunology (Orlando, Fla.) - 1 Aug 2009
Buraczynska Monika, Ksiazek Piotr, Zukowski Pawel, Benedyk-Lorens Ewa, Orlowska-Kowalik Grazyna
Abstract excerpt
The main cause of increased mortality in end-stage renal disease (ESRD) is cardiovascular disease (CVD). Complement factor H (CFH) may affect risk of CVD. Our study investigates a role of CFH Y402H polymorphism as a potential risk factor of CVD in a large group of patients. A group of 1200 patients with ESRD and 818 healthy controls were genotyped for the Y402H (T1277C) polymorphism. There was a significant...
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