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Article

Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese population.

PloS one - 1 Jan 2012

Gan Wei, Wu Johnna, Lu Ling, Xiao Xu, Huang Heng, Wang Fulong, Zhu Jingwen, Sun Liang, Liu Gang, Pan Yi, Li Huaixing, Lin Xu, Chen Yan

Abstract excerpt

Dysregulation of the complement system has been linked to pathogenesis of hypertension. However, whether genetic changes of complement factor H (CFH) and its related genes are associated with hypertension is unknown. We genotyped three SNPs in the CFH gene cluster that are closely linked to age-related macular degeneration, namely rs1061170 (Y402H), rs2274700 (A473A) and rs7542235 (CFHR1-3Δ), and tested for their...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22848687
DOI: 10.1371/journal.pone.0042010
PMCID: PMC3405009

Genes

CFH
CFHR1
CRP
DBP
CFHR3

Variants

rs1061170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Associations of CFH polymorphisms and CFHR1-CFHR3 deletion with blood pressure and hypertension in Chinese population.PMID 22848687Read ↗

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CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration.Semantic proximity Read ↗

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Association of complement factor H polymorphisms with exudative age-related macular degeneration.Semantic proximity Read ↗

A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration.Semantic proximity Read ↗

Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals.Semantic proximity Read ↗

A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration.Semantic proximity Read ↗

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A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration.Semantic proximity Read ↗

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