Article
Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations.
Journal of medical genetics - 1 Jun 2008
Kristjansdottir G, Sandling J K, Bonetti A, Roos I M, Milani L, Wang C, Gustafsdottir S M, Sigurdsson S, Lundmark A, Tienari P J, Koivisto K, Elovaara I, Pirttilä T, Reunanen M, Peltonen L, Saarela J, Hillert J, Olsson T, Landegren U, Alcina A, Fernández O, Leyva L, Guerrero M, Lucas M, Izquierdo G, Matesanz F, Syvänen A-C
Abstract excerpt
BACKGROUND: IRF5 is a transcription factor involved both in the type I interferon and the toll-like receptor signalling pathways. Previously, IRF5 has been found to be associated with systemic lupus erythematosus, rheumatoid arthritis and inflammatory bowel diseases. Here we investigated whether polymorphisms in the IRF5 gene would be associated with yet another disease with features of autoimmunity, multiple...
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