Article
An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases.
Human molecular genetics - 15 Dec 2007
Dideberg Vinciane, Kristjansdottir Gudlaug, Milani Lili, Libioulle Cécile, Sigurdsson Snaevar, Louis Edouard, Wiman Ann-Christin, Vermeire Séverine, Rutgeerts Paul, Belaiche Jacques, Franchimont Denis, Van Gossum André, Bours Vincent, Syvänen Ann-Christine
Abstract excerpt
The interferon regulatory factor 5 (IRF5) gene encodes a transcription factor that plays an important role in the innate as well as in the cell-mediated immune responses. The IRF5 gene has been shown to be associated with systemic lupus erythematosus and rheumatoid arthritis. We studied whether the IRF5 gene is also associated with inflammatory bowel diseases (IBD), Crohn disease (CD) and ulcerative colitis (UC)....
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