Article
Interferon regulatory factor 5 gene polymorphism confers risk to several rheumatic diseases and correlates with expression of alternative thymic transcripts.
Rheumatology (Oxford, England) - 1 Apr 2012
Nordang Gry B N, Viken Marte K, Amundsen Silja S, Sanchez Elena S, Flatø Berit, Førre Oystein T, Martin Javier, Kvien Tore K, Lie Benedicte A
Abstract excerpt
OBJECTIVES: Polymorphisms in genes related to the IFN pathway were investigated for susceptibility to rheumatic diseases and correlation with gene expression in thymus. METHODS: Forty-five polymorphisms were genotyped in Norwegian patients with RA (n = 518), JIA (n = 440), SLE (n = 154) and healthy controls (n = 756). Forty-two thymic samples were used for gene expression analysis. Six hundred and fifty SLE...
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