Identification of three new cis-regulatory IRF5 polymorphisms: in vitro studies.

doi:10.1186/ar4262

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Article

Identification of three new cis-regulatory IRF5 polymorphisms: in vitro studies.

Arthritis research & therapy - 13 Aug 2013

Alonso-Perez Elisa, Fernandez-Poceiro Romina, Lalonde Emilie, Kwan Tony, Calaza Manuel, Gomez-Reino Juan J, Majewski Jacek, Gonzalez Antonio

Abstract excerpt

BACKGROUND: Polymorphisms in the interferon regulatory factor 5 (IRF5) gene are associated with susceptibility to systemic lupus erythematosus, rheumatoid arthritis and other diseases through independent risk and protective haplotypes. Several functional polymorphisms are already known, but they do not account for the protective haplotypes that are tagged by the minor allele of rs729302. METHODS: Polymorphisms in...

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PMID: 23941291
DOI: 10.1186/ar4262
PMCID: PMC3978921

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