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Article

Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.

The Journal of biological chemistry - 18 Apr 2008

Kumánovics Attila, Chen Opal S, Li Liangtao, Bagley Dustin, Adkins Erika M, Lin Huilan, Dingra Nin N, Outten Caryn E, Keller Greg, Winge Dennis, Ward Diane M, Kaplan Jerry

Abstract excerpt

The nature of the connection between mitochondrial Fe-S cluster synthesis and the iron-sensitive transcription factor Aft1 in regulating the expression of the iron transport system in Saccharomyces cerevisiae is not known. Using a genetic screen, we identified two novel cytosolic proteins, Fra1 and Fra2, that are part of a complex that interprets the signal derived from mitochondrial Fe-S synthesis. We found that...

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Identifiers

PMID: 18281282
DOI: 10.1074/jbc.M801160200
PMCID: PMC2447656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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