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Article

Turning Saccharomyces cerevisiae into a Frataxin-Independent Organism.

PLoS genetics - 1 May 2015

Yoon Heeyong, Knight Simon A B, Pandey Alok, Pain Jayashree, Turkarslan Serdar, Pain Debkumar, Dancis Andrew

Abstract excerpt

Frataxin (Yfh1 in yeast) is a conserved protein and deficiency leads to the neurodegenerative disease Friedreich's ataxia. Frataxin is a critical protein for Fe-S cluster assembly in mitochondria, interacting with other components of the Fe-S cluster machinery, including cysteine desulfurase Nfs1...

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Identifiers

PMID: 25996596
DOI: 10.1371/journal.pgen.1005135
PMCID: PMC4440810

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25996596-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Turning Saccharomyces cerevisiae into a Frataxin-Independent Organism.PMID 25996596Read ↗

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Turning Escherichia coli into a Frataxin-Dependent Organism.Semantic proximity Read ↗

Acidic residues of yeast frataxin have an essential role in Fe-S cluster assembly.Semantic proximity Read ↗

Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency.Semantic proximity Read ↗

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