Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.

The Journal of biological chemistry - 14 Dec 2012

Gabrielli Natalia, Ayté José, Hidalgo Elena

Abstract excerpt

Friedreich ataxia is a genetic disease caused by deficiencies in frataxin. This protein has homologs not only in higher eukaryotes but also in bacteria, fungi, and plants. The function of this protein is still controversial. We have identified a frataxin homolog in fission yeast, and we have analyzed whether its depletion leads to any of the phenotypes observed in other organisms. Cells deleted in pfh1 are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Helicases
Share to Frataxin
Share to Iron-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Iron Deficiencies

Share to Mammals

Share to Proteome

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23115244
DOI: 10.1074/jbc.M112.421735
PMCID: PMC3522298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.PMID 23115244Read ↗

Oxidative stress and protease dysfunction in the yeast model of Friedreich ataxia.Semantic proximity Read ↗

Iron metabolism and mitochondrial abnormalities in Friedreich ataxia.Semantic proximity Read ↗

The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins.Semantic proximity Read ↗

Yeast frataxin mutants display decreased superoxide dismutase activity crucial to promote protein oxidative damage.Semantic proximity Read ↗

Major targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins.Semantic proximity Read ↗

Functional and molecular characterization of the frataxin homolog from Arabidopsis thaliana.Semantic proximity Read ↗

Mitochondrial iron detoxification is a primary function of frataxin that limits oxidative damage and preserves cell longevity.Semantic proximity Read ↗

The mitochondrial protein frataxin prevents nuclear damage.Semantic proximity Read ↗

Zinc suppresses the iron-accumulation phenotype of Saccharomyces cerevisiae lacking the yeast frataxin homologue (Yfh1).Semantic proximity Read ↗

Frataxin: a protein in search for a function.Semantic proximity Read ↗

Oxidative stress studies in yeast with a frataxin mutant: a proteomics perspective.Semantic proximity Read ↗

Reduction of Caenorhabditis elegans frataxin increases sensitivity to oxidative stress, reduces lifespan, and causes lethality in a mitochondrial complex II mutant.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.