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Article

Iron toxicity protection by truncated Ras2 GTPase in yeast strain lacking frataxin.

Biochemical and biophysical research communications - 24 Oct 2003

Kucej Martin, Foury Françoise

Abstract excerpt

Yeast strain deleted for the YFH1 gene, which encodes the orthologue of human frataxin, accumulates iron in mitochondria, constitutively activates the high-affinity iron import system in the plasma membrane, and is sensitive to high iron media. We have performed a genetic screen for mutants of a yfh1 deleted strain with increased resistance to high levels of iron. One of the identified mutations caused the...

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PMID: 14550302
DOI: 10.1016/j.bbrc.2003.09.115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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