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Article

Mrs3p, Mrs4p, and frataxin provide iron for Fe-S cluster synthesis in mitochondria.

The Journal of biological chemistry - 11 Aug 2006

Zhang Yan, Lyver Elise R, Knight Simon A B, Pain Debkumar, Lesuisse Emmanuel, Dancis Andrew

Abstract excerpt

Yeast Mrs3p and Mrs4p are evolutionarily conserved mitochondrial carrier proteins that transport iron into mitochondria under some conditions. Yeast frataxin (Yfh1p), the homolog of the human protein implicated in Friedreich ataxia, is involved in iron homeostasis. However, its precise functions...

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Identifiers

PMID: 16769722
DOI: 10.1074/jbc.M604246200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16769722-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Mrs3p, Mrs4p, and frataxin provide iron for Fe-S cluster synthesis in mitochondria.PMID 16769722Read ↗

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Salutary Effects of Overexpression of Rsm22, an Assembly Factor for the Mitochondrial Ribosome, on Frataxin/Yfh1 Depletion Phenotypes in Saccharomyces cerevisiae.Semantic proximity Read ↗

The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins.Semantic proximity Read ↗

Cells lacking pfh1, a fission yeast homolog of mammalian frataxin protein, display constitutive activation of the iron starvation response.Semantic proximity Read ↗

Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.Semantic proximity Read ↗

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Recent Advances in the Elucidation of Frataxin Biochemical Function Open Novel Perspectives for the Treatment of Friedreich’s AtaxiaSemantic proximity Read ↗

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