Article
Yeast frataxin mutants display decreased superoxide dismutase activity crucial to promote protein oxidative damage.
Free radical biology & medicine - 1 Feb 2010
Irazusta Verónica, Obis Elia, Moreno-Cermeño Armando, Cabiscol Elisa, Ros Joaquim, Tamarit Jordi
Abstract excerpt
Iron overload is involved in several pathological conditions, including Friedreich ataxia, a disease caused by decreased expression of the mitochondrial protein frataxin. In a previous study, we identified 14 proteins selectively oxidized in yeast cells lacking Yfh1, the yeast frataxin homolog. Most of these were magnesium-binding proteins. Decreased Mn-SOD activity, oxidative damage to CuZn-SOD, and increased...
Topics
- Copper
- Electrophoresis, Gel, Two-Dimensional
- Gene Expression Regulation, Fungal
- Iron
- Iron-Binding Proteins
- Manganese
- Mutation
- Oxidation-Reduction
- Oxidative Stress
- Proteins