Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast.

The Journal of biological chemistry - 7 Jan 2011

Li Haoran, Mapolelo Daphne T, Dingra Nin N, Keller Greg, Riggs-Gelasco Pamela J, Winge Dennis R, Johnson Michael K, Outten Caryn E

Abstract excerpt

The BolA homologue Fra2 and the cytosolic monothiol glutaredoxins Grx3 and Grx4 together play a key role in regulating iron homeostasis in Saccharomyces cerevisiae. Genetic studies indicate that Grx3/4 and Fra2 regulate activity of the iron-responsive transcription factors Aft1 and Aft2 in response to mitochondrial Fe-S cluster biosynthesis. We have previously shown that Fra2 and Grx3/4 form a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoproteins
Share to Histidine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oxidoreductases

Share to Protein Multimerization

Share to Protein Stability

Share to Protein Structure, Quaternary

Share to Spectrum Analysis

Share to Sulfur

Source

Open in PubMed Open full text

Identifiers

PMID: 20978135
DOI: 10.1074/jbc.M110.184176
PMCID: PMC3013046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histidine 103 in Fra2 is an iron-sulfur cluster ligand in the [2Fe-2S] Fra2-Grx3 complex and is required for in vivo iron signaling in yeast.PMID 20978135Read ↗

Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis.Semantic proximity Read ↗

Proteomic profiling of the monothiol glutaredoxin Grx3 reveals its global role in the regulation of iron dependent processes.Semantic proximity Read ↗

The E. coli monothiol glutaredoxin GrxD forms homodimeric and heterodimeric FeS cluster containing complexes.Semantic proximity Read ↗

Biochemical impact of a disease-causing Ile67Asn substitution on BOLA3 protein.Semantic proximity Read ↗

Understanding the Molecular Basis of the Multiple Mitochondrial Dysfunctions Syndrome 2: The Disease-Causing His96Arg Mutation of BOLA3.Semantic proximity Read ↗

In vivo fluorescent detection of Fe-S clusters coordinated by human GRX2.Semantic proximity Read ↗

Molecular Basis of Multiple Mitochondrial Dysfunctions Syndrome 2 Caused by CYS59TYR BOLA3 Mutation.Semantic proximity Read ↗

Functional transitions of the Aspergillus fumigatus iron regulator HapX are governed by conserved domains cooperatively binding [2Fe-2S] clustersSemantic proximity Read ↗

Mrs3p, Mrs4p, and frataxin provide iron for Fe-S cluster synthesis in mitochondria.Semantic proximity Read ↗

Oxidative stress studies in yeast with a frataxin mutant: a proteomics perspective.Semantic proximity Read ↗

Assembly of the iron-binding protein frataxin in Saccharomyces cerevisiae responds to dynamic changes in mitochondrial iron influx and stress level.Semantic proximity Read ↗

Yeast frataxin mutants display decreased superoxide dismutase activity crucial to promote protein oxidative damage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.