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Article

Reduction in frataxin causes progressive accumulation of mitochondrial damage.

Human molecular genetics - 15 Dec 2003

Karthikeyan Gopalakrishnan, Santos Janine H, Graziewicz Maria A, Copeland William C, Isaya Grazia, Van Houten Bennett, Resnick Michael A

Abstract excerpt

Frataxin protein controls iron availability in mitochondria and reduced levels lead to the human disease, Friedreich's ataxia (FRDA). The molecular aspects of disease progression are not well understood. We developed a highly regulatable promoter system for expressing frataxin in yeast to address...

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Source

Identifiers

PMID: 14570713
DOI: 10.1093/hmg/ddg349

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14570713-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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