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Article

Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements.

The Journal of biological chemistry - 25 Jul 2003

Rutherford Julian C, Jaron Shulamit, Winge Dennis R

Abstract excerpt

The transcription factors Aft1p and Aft2p from Saccharomyces cerevisiae regulate the expression of genes that are involved in iron homeostasis. In vitro studies have shown that both transcription factors bind to an iron-responsive element (FeRE) that is present in the upstream region of genes in the iron regulon. We have used DNA microarrays to distinguish the genes that are activated by Aft1p and Aft2p and to...

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PMID: 12756250
DOI: 10.1074/jbc.M300076200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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