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Article

Iron-induced dissociation of the Aft1p transcriptional regulator from target gene promoters is an initial event in iron-dependent gene suppression.

Molecular and cellular biology - 1 Dec 2012

Ueta Ryo, Fujiwara Naoko, Iwai Kazuhiro, Yamaguchi-Iwai Yuko

Abstract excerpt

Aft1p is an iron-responsive transcriptional activator that plays a central role in the regulation of iron metabolism in Saccharomyces cerevisiae. Aft1p is regulated by accelerated nuclear export in the presence of iron, mediated by Msn5p. However, the transcriptional activity of Aft1p is suppressed under iron-replete conditions in the Δmsn5 strain, although Aft1p remains in the nucleus. Aft1p dissociates from its...

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PMID: 23045394
DOI: 10.1128/MCB.00726-12
PMCID: PMC3510542

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