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Article

Genetic dissection of a mitochondria-vacuole signaling pathway in yeast reveals a link between chronic oxidative stress and vacuolar iron transport.

The Journal of biological chemistry - 2 Apr 2010

Li Liangtao, Murdock Grace, Bagley Dustin, Jia Xuan, Ward Diane McVey, Kaplan Jerry

Abstract excerpt

Deletion of two homologous genes, MRS3 and MRS4, that encode mitochondrial iron transporters affects the activity of the vacuolar iron importer Ccc1. Ccc1 levels are decreased in Deltamrs3Deltamrs4 cells, but the activity of the transporter is increased, resulting is reduced cytosolic iron. Overe...

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Identifiers

PMID: 20139087
DOI: 10.1074/jbc.M109.096859
PMCID: PMC2856228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20139087-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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