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Chitinase-3-like 1 (CHI3L1) gene and schizophrenia: genetic association and a potential functional mechanism.

Biological psychiatry - 15 Jul 2008

Yang Mao Sheng, Morris Derek W, Donohoe Gary, Kenny Elaine, O'Dushalaine Colm T, Schwaiger Siobhan, Nangle Jeanne Marie, Clarke Sarah, Scully Paul, Quinn John, Meagher David, Baldwin Patrizia, Crumlish Niall, O'Callaghan Eadbhard, Waddington John L, Gill Michael, Corvin Aiden

Abstract excerpt

BACKGROUND: Gene expression data and association analyses in two Chinese samples implicate chitinase 3-like 1 (CHI3L1), a cellular survival gene, in schizophrenia susceptibility. METHODS: We tested whether the association data are robust to replication in a Caucasian schizophrenia sample and performed a comprehensive investigation of common genetic variation at the locus. RESULTS: In a sample of 375 case and 812...

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PMID: 18281018
DOI: 10.1016/j.biopsych.2007.12.012

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EBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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