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Article

The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.

Schizophrenia research - 1 Feb 2010

Ohi Kazutaka, Hashimoto Ryota, Yasuda Yuka, Yoshida Tetsuhiko, Takahashi Hidetoshi, Iike Naomi, Iwase Masao, Kamino Kouzin, Ishii Ryouhei, Kazui Hiroaki, Fukumoto Motoyuki, Takamura Hironori, Yamamori Hidenaga, Azechi Michiyo, Ikezawa Koji, Tanimukai Hitoshi, Tagami Shinji, Morihara Takashi, Okochi Masayasu, Yamada Kazuo, Numata Shusuke, Ikeda Masashi, Tanaka Toshihisa, Kudo Takashi, Ueno Shu-Ichi, Yoshikawa Takeo, Ohmori Tetsuro, Iwata Nakao, Ozaki Norio, Takeda Masatoshi

Abstract excerpt

The chitinase 3-like 1 (CHI3L1) gene acts as a cellular survival factor in response to several environmental and psychosocial stresses. The expression level of CHI3L1 was increased in the hippocampus and prefrontal cortex regions of patients with schizophrenia. Genetic variants of the CHI3L1 gene...

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Identifiers

PMID: 20051317
DOI: 10.1016/j.schres.2009.12.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20051317-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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