Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia.

American journal of human genetics - 1 Jan 2007

Zhao Xinzhi, Tang Ruqi, Gao Bo, Shi Yongyong, Zhou Jian, Guo Shengzhen, Zhang Jing, Wang Yabing, Tang Wei, Meng Junwei, Li Sheng, Wang Hongsheng, Ma Gang, Lin Chuwen, Xiao Yue, Feng Guoyin, Lin Zhiguang, Zhu Shaomin, Xing Yangling, Sang Hong, St Clair David, He Lin

Abstract excerpt

The chitinase 3-like 1 gene (CHI3L1) is abnormally expressed in the hippocampus of subjects with schizophrenia and may be involved in the cellular response to various environmental events that are reported to increase the risk of schizophrenia. Here, we provide evidence that the functional variants at the CHI3L1 locus influence the genetic risk of schizophrenia. First, using case-control and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines
Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chitinase-3-Like Protein 1

Share to Genes, myc

Share to Glycoproteins

Share to Lectins

Share to Schizophrenia

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 17160890
DOI: 10.1086/510438
PMCID: PMC1785314

Genes

MAX
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia.PMID 17160890Read ↗

Chitinase-3-like 1 (CHI3L1) gene and schizophrenia: genetic association and a potential functional mechanism.Semantic proximity Read ↗

The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis.Semantic proximity Read ↗

Failure to confirm genetic association of the CHI3L1 gene with schizophrenia in Japanese and Chinese populations.Semantic proximity Read ↗

A promoter variant in the chitinase 3-like 1 gene is associated with serum YKL-40 level and personality trait.Semantic proximity Read ↗

Allelic expression imbalance of the schizophrenia susceptibility gene CHI3L1: evidence of cis-acting variation and tissue specific regulation.Semantic proximity Read ↗

Genetic variation in the promoter region of chitinase 3-like 1 is associated with atopy.Semantic proximity Read ↗

Two-stage additional evidence support association of common variants in the HDAC3 with the increasing risk of schizophrenia susceptibility.Semantic proximity Read ↗

Correlation of Chitinase 3-Like 1 Single Nucleotide Polymorphisms with Hepatocellular Carcinoma in Taiwan.Semantic proximity Read ↗

Functional variants of the chitinase 3-like 1 gene are associated with clinicopathologic outcomes and progression of prostate cancer.Semantic proximity Read ↗

Chitinase 3-like 1 polymorphisms and risk of chronic obstructive pulmonary disease and asthma in a Chinese population.Semantic proximity Read ↗

The role of the Chitinase 3-Like 1 (CHI3L1) genes in the preeclampsia pathophysiology.Semantic proximity Read ↗

Evaluation of polymorphism, hypermethylation and expression pattern of CTLA4 gene in a sample of Iranian patients with schizophrenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.