Functional variants of the chitinase 3-like 1 gene are associated with clinicopathologic outcomes and progression of prostate cancer.

doi:10.1111/jcmm.18012

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Article

Functional variants of the chitinase 3-like 1 gene are associated with clinicopathologic outcomes and progression of prostate cancer.

Journal of cellular and molecular medicine - 1 Dec 2023

Wen Yu-Ching, Lin Chia-Yen, Ho Kuo-Hao, Lin Yung-Wei, Hsiao Chi-Hao, Wang Shian-Shiang, Chang Lun-Ching, Yang Shun-Fa, Chien Ming-Hsien

Abstract excerpt

Chitinase 3-like 1 (CHI3L1 or YKL40) is a secreted glycoprotein highly expressed in advanced stages of several cancer types, including prostate cancer (PCa). Impacts of genetic variants of CHI3L1 on PCa development have not yet been investigated. The most common well-studied genetic variations are single-nucleotide polymorphisms (SNPs). Therefore, the objective of this study was to explore associations of CHI3L1...

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PMID: 37902124
DOI: 10.1111/jcmm.18012
PMCID: PMC10746933

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