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Article

The E1B 19,000-molecular-weight protein of group C adenoviruses prevents tumor necrosis factor cytolysis of human cells but not of mouse cells.

Journal of virology - 1 Jun 1991

Gooding L R, Aquino L, Duerksen-Hughes P J, Day D, Horton T M, Yei S P, Wold W S

Abstract excerpt

Tumor necrosis factor (TNF) is a multifunctional immunoregulatory protein that is secreted by activated macrophages and is believed to have antiviral activities. We reported earlier that when mouse C3HA fibroblasts are infected with human adenoviruses, the 289R and 243R proteins encoded by region E1A render the cells susceptible to lysis by TNF, and a 14,700-molecular-weight protein (14.7K protein) encoded by...

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Source

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Identifiers

PMID: 1827845
DOI: 10.1128/JVI.65.6.3083-3094.1991
PMCID: PMC240964

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The E1B 19,000-molecular-weight protein of group C adenoviruses prevents tumor necrosis factor cytolysis of human cells but not of mouse cells.PMID 1827845Read ↗

The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus function together to protect many but not all mouse cell lines against lysis by tumor necrosis factor.Semantic proximity Read ↗

The amino-terminal portion of CD1 of the adenovirus E1A proteins is required to induce susceptibility to tumor necrosis factor cytolysis in adenovirus-infected mouse cells.Semantic proximity Read ↗

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Human cytomegalovirus IE1 and IE2 proteins block apoptosisSemantic proximity Read ↗

Adenovirus E1B 19-kilodalton protein modulates innate immunity through apoptotic mimicry.Semantic proximity Read ↗

Three distinct cell phenotypes of induced-TNF cytotoxicity and their relationship to apoptosis.Semantic proximity Read ↗

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Activation of transcription factor NF-kappaB by the adenovirus E3/19K protein requires its ER retention.Semantic proximity Read ↗

E1A and E1B proteins inhibit inflammation induced by adenovirus.Semantic proximity Read ↗

Overexpression of the E1B 55-kilodalton (482R) protein of human adenovirus type 12 appears to permit efficient transformation of primary baby rat kidney cells in the absence of the E1B 19-kilodalton protein.Semantic proximity Read ↗

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