Augmentation by IL-1 alpha of tumor necrosis factor-alpha cytotoxicity in cells transfected with adenovirus E1A.

Article

Augmentation by IL-1 alpha of tumor necrosis factor-alpha cytotoxicity in cells transfected with adenovirus E1A.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1993

Tsuji Y, Ninomiya-Tsuji J, Torti S V, Torti F M

Abstract excerpt

The introduction of adenovirus E1A into NIH3T3 mouse fibroblasts renders them susceptible to the cytotoxic action of TNF-alpha. We found that cells transfected with 13S E1A cDNA were not similarly rendered sensitive to IL-1 alpha; however, in cells transfected with 13S E1A cDNA, TNF cytotoxicity...

Topics

3T3 Cells
Adenovirus E1A Proteins
Animals
Cell Survival
Drug Synergism
Interleukin-1
Mice
Mutation
Retinoblastoma Protein
Structure-Activity Relationship
Transfection
Tumor Necrosis Factor-alpha

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