Article
The amino-terminal portion of CD1 of the adenovirus E1A proteins is required to induce susceptibility to tumor necrosis factor cytolysis in adenovirus-infected mouse cells.
Journal of virology - 1 Mar 1991
Duerksen-Hughes P J, Hermiston T W, Wold W S, Gooding L R
Abstract excerpt
Previous work by our laboratory and others has shown that mouse cells normally resistant to tumor necrosis factor can be made sensitive to the cytokine by the expression of adenovirus E1A. The E1A gene can be introduced by either infection or transfection, and either of the two major E1A proteins, 289R or 243R, can induce this sensitivity. The E1A proteins are multifunctional and modular, with specific domains...
Topics
- Adenovirus Early Proteins
- Adenoviruses, Human
- Animals
- Cell Line
- Cell Survival
- Cell Transformation, Viral
- Enhancer Elements, Genetic
- Humans
- Kinetics
- Mice
- Mutation