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Article

E1A and E1B proteins inhibit inflammation induced by adenovirus.

Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 2004

Schaack Jerome, Bennett Michael L, Colbert Jeff D, Torres Andres Vazquez, Clayton Gerald H, Ornelles David, Moorhead John

Abstract excerpt

Replication-defective human adenovirus (Ad) group C transducing vectors, most of which have the E1A, E1B, and E3 genes deleted, are highly inflammatory despite the fact that the parental viruses typically cause subclinical or mild infections. To investigate this paradox, the roles that the E1A, E1B, and E3 genes play in inflammation were tested by using replication-incompetent viruses carrying a deletion of the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 14976240
DOI: 10.1073/pnas.0303709101
PMCID: PMC365754

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Source receipt: pubmed, retrieved 7 Sept 2026.

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