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Article

Human cytomegalovirus IE1 and IE2 proteins block apoptosis

1 Dec 1995

Abstract excerpt

Human cytomegalovirus-infected fibroblasts are resistant to the induction of apoptosis by superinfection with a mutant adenovirus unable to produce the viral E1B 19-kDa protein that normally causes an E1A protein-mediated apoptotic response. Two cytomegalovirus gene products that block apoptosis were identified. The IE1 and IE2 proteins each inhibit the induction of apoptosis by tumor necrosis factor alpha or by...

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Identifiers

PMID: 7494309
DOI: 10.1128/jvi.69.12.7960-7970.1995

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