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Article

Specificity determinants of a novel Nck interaction with the juxtamembrane domain of the epidermal growth factor receptor.

Biochemistry - 11 Mar 2008

Hake Michael J, Choowongkomon Kiattawee, Kostenko Olga, Carlin Cathleen R, Sönnichsen Frank D

Abstract excerpt

Nck is a ubiquitously expressed adaptor protein containing Src homology 2 (SH2) and Src homology 3 (SH3) domains. It integrates downstream effector proteins with cell membrane receptors, such as the epidermal growth factor receptor (EGFR). EGFR plays a critical role in cellular proliferation and differentiation. The 45-residue juxtamembrane domain of EGFR (JM), located between the transmembrane and kinase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18269246
DOI: 10.1021/bi701549a

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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