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Article

The juxtamembrane region of the EGF receptor functions as an activation domain.

Molecular cell - 26 Jun 2009

Red Brewer Monica, Choi Sung Hee, Alvarado Diego, Moravcevic Katarina, Pozzi Ambra, Lemmon Mark A, Carpenter Graham

Abstract excerpt

In several growth factor receptors, the intracellular juxtamembrane (JM) region participates in autoinhibitory interactions that must be disrupted for tyrosine kinase activation. Using alanine scanning mutagenesis and crystallographic approaches, we define a domain within the JM region of the epidermal growth factor receptor (EGFR) that instead plays an activating--rather than autoinhibitory--role. Mutations in...

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Source

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Identifiers

PMID: 19560417
DOI: 10.1016/j.molcel.2009.04.034
PMCID: PMC2719887

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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