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Article

Interactions of the EGFR juxtamembrane domain with PIP2-containing lipid bilayers: Insights from multiscale molecular dynamics simulations.

Biochimica et biophysica acta - 1 May 2015

Abd Halim Khairul Bariyyah, Koldsø Heidi, Sansom Mark S P

Abstract excerpt

BACKGROUND: The epidermal growth factor receptor (EGFR) is the best characterised member of the receptor tyrosine kinases, which play an important role in signalling across mammalian cell membranes. The EGFR juxtamembrane (JM) domain is involved in the mechanism of activation of the receptor, interacting with the anionic lipid phosphatidylinositol 4,5-bisphosphate (PIP2) in the intracellular leaflet of the cell...

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Identifiers

PMID: 25219456
DOI: 10.1016/j.bbagen.2014.09.006
PMCID: PMC4547087

Genes

EGFR

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