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Article

Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3.

The Biochemical journal - 15 Dec 2005

Lipina Christopher, Huang Xu, Finlay David, McManus Edward J, Alessi Dario R, Sutherland Calum

Abstract excerpt

GSK3 (glycogen synthase kinase-3) regulation is proposed to play a key role in the hormonal control of many cellular processes. Inhibition of GSK3 in animal models of diabetes leads to normalization of blood glucose levels, while high GSK3 activity has been reported in Type II diabetes. Insulin inhibits GSK3 by promoting phosphorylation of a serine residue (Ser-21 in GSK3alpha, Ser-9 in GSK3beta), thereby...

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Source

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Identifiers

PMID: 16176184
DOI: 10.1042/BJ20051046
PMCID: PMC1316304

Genes

IGFBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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