Article
Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.
Diabetes - 1 Aug 1999
Eldar-Finkelman H, Schreyer S A, Shinohara M M, LeBoeuf R C, Krebs E G
Abstract excerpt
Although the precise mechanisms contributing to insulin resistance and type 2 diabetes are unknown, it is believed that defects in downstream components of the insulin signaling pathway may be involved. In this work, we hypothesize that a serine/threonine kinase, glycogen synthase kinase-3 (GSK-3...
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