Article
Involvement of SIK3 in glucose and lipid homeostasis in mice.
PloS one - 1 Jan 2012
Uebi Tatsuya, Itoh Yumi, Hatano Osamu, Kumagai Ayako, Sanosaka Masato, Sasaki Tsutomu, Sasagawa Satoru, Doi Junko, Tatsumi Keita, Mitamura Kuniko, Morii Eiichi, Aozasa Katsuyuki, Kawamura Tomohiro, Okumura Meinoshin, Nakae Jun, Takikawa Hajime, Fukusato Toshio, Koura Minako, Nish Mayumi, Hamsten Anders, Silveira Angela, Bertorello Alejandro M, Kitagawa Kazuo, Nagaoka Yasuo, Kawahara Hidehisa, Tomonaga Takeshi, Naka Tetsuji, Ikegawa Shigeo, Tsumaki Noriyuki, Matsuda Junichiro, Takemori Hiroshi
Abstract excerpt
Salt-inducible kinase 3 (SIK3), an AMP-activated protein kinase-related kinase, is induced in the murine liver after the consumption of a diet rich in fat, sucrose, and cholesterol. To examine whether SIK3 can modulate glucose and lipid metabolism in the liver, we analyzed phenotypes of SIK3-deficent mice. Sik3(-/-) mice have a malnourished the phenotype (i.e., lipodystrophy, hypolipidemia, hypoglycemia, and...
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