Article
Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.
Proceedings of the National Academy of Sciences of the United States of America - 8 Aug 2006
Taniguchi Cullen M, Tran Thien T, Kondo Tatsuya, Luo Ji, Ueki Kohjiro, Cantley Lewis C, Kahn C Ronald
Abstract excerpt
The phosphoinositide 3-kinase (PI3K) pathway is central to the metabolic actions of insulin on liver. Here, we show that mice with a liver-specific deletion of the p85alpha regulatory subunit of PI3K (L-Pik3r1KO) exhibit a paradoxical improvement of hepatic and peripheral insulin sensitivity. Although PI3K enzymatic activity is diminished in L-Pik3r1KO livers because of a reduced level of regulatory and catalytic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.