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Article

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

The Journal of clinical investigation - 1 Feb 2003

Heximer Scott P, Knutsen Russell H, Sun Xiaoguang, Kaltenbronn Kevin M, Rhee Man-Hee, Peng Ning, Oliveira-dos-Santos Antonio, Penninger Josef M, Muslin Anthony J, Steinberg Thomas H, Wyss J Michael, Mecham Robert P, Blumer Kendall J

Abstract excerpt

Signaling by hormones and neurotransmitters that activate G protein-coupled receptors (GPCRs) maintains blood pressure within the normal range despite large changes in cardiac output that can occur within seconds. This implies that blood pressure regulation requires precise kinetic control of GPCR signaling. To test this hypothesis, we analyzed mice deficient in RGS2, a GTPase-activating protein that greatly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12588882
DOI: 10.1172/JCI15598
PMCID: PMC151918

Genes

RGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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