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Article

Deregulation of RGS2 in cardiovascular diseases

17 Dec 2009

Abstract excerpt

Alteration of G protein-coupled receptor (GPCR) signaling is a salient feature of hypertension and the associated heart diseases. Recent studies have revealed a large family of Regulators of G-protein Signaling (RGS) proteins as important endogenous regulators of GPCR signaling. RGS2 selectively regulates Galphaq/11 signaling, an essential cause of hypertension and cardiac hypertrophy. Both clinical and animal...

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PMID: 20036967
DOI: 10.2741/s84

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