Article
CREG promotes a mature smooth muscle cell phenotype and reduces neointimal formation in balloon-injured rat carotid artery.
Cardiovascular research - 1 Jun 2008
Han Yaling, Deng Jie, Guo Liang, Yan Chenghui, Liang Ming, Kang Jian, Liu Haiwei, Graham Alan M, Li Shaohua
Abstract excerpt
AIM: We previously showed that cellular repressor of E1A-stimulated genes (CREG) is up-regulated during serum starvation-induced vascular smooth muscle cell (SMC) differentiation. The aim of this study was to determine the role of CREG in maintaining the quiescent, differentiated phenotype of SMCs both in culture and in balloon-injured rat carotid artery. METHODS AND RESULTS: In cultured SMCs recombinant...
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